L-methylfolate/pyridoxal 5-phosphate/methylcobalamin: Uses, Warnings, Side Effects


What is L-methylfolate/pyridoxal 5-phosphate/methylcobalamin, and what is it used for?

L-methylfolate/pyridoxal 5-phosphate/methylcobalamin is a combination of three vitamins of the B group. L-methylfolate is the active form of vitamin B9, also known as folate, pyridoxal 5-phosphate is the active form of vitamin B6 and methylcobalamin is one of the two active forms of vitamin B12. The combination of B vitamins is a prescription medical food used under a physician’s supervision, to treat peripheral diabetic neuropathy.

Peripheral diabetic neuropathy is a kind of nerve damage caused by excessive sugar levels in patients with diabetes mellitus type II. The combination of the three water-soluble vitamins B9, B6 and B12 is specifically formulated to provide the nutritional supplements required to improve peripheral blood flow, and reduce nerve damage and neuropathy in diabetic patients.

L-methylfolate is a coenzyme crucial for many cellular functions including metabolism of amino acids, DNA and RNA synthesis, and the synthesis and growth of all cells, particularly, red blood cells. Pyridoxal 5-phosphate is a coenzyme involved in protein synthesis, has multiple functions, and is essential for normal brain development and for keeping the nervous system and immune system healthy. Methylcobalamin is another micronutrient that is important for healthy functioning of the nervous system, formation of red blood cells and DNA synthesis.

The three B vitamins are naturally available in many foods, but diabetic patients with neuropathy often require supplemental amounts. Good dietary sources of folate include leafy green vegetables, legumes, eggs, beef liver, fruits and vegetables. Vitamin B6 rich foods include fish, beef liver and other organ meats, potatoes and other starchy vegetables, and fruit (other than citrus). Vitamin B12 sources include fish, meat, poultry, eggs, dairy and B12 fortified products such as breakfast cereals.



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